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The legendary rock band, which has won 22 Grammys, performed for two hours inside the massive, state-of-the-art spherical venue with crystal-clear audio. Throughout the night, there were a plethora of attractive visuals — including kaleidoscope images, a burning flag and Las Vegas’ skyline, taking the more than 18,000 attendees on U2’s epic musical journey.

“What a fancy pad,� said Bono, who was accompanied onstage with guitarists The Edge and Adam Clayton along with drummer Bram van den Berg. He then stared at the high-resolution LED screen that projected a larger version of himself along with a few praying hands and bells.

Bono then paid homage to the late Elvis Presley, who was a Las Vegas entertainment staple. The band has rocked in the city as far back as 1987 when they filmed the music video for “I Still Haven't Found What I'm Looking For� on the Strip during a tour in 1987.

“Look at all this stuff. … Elvis has definitely not left this building,� he continued. “It’s an Elvis chapel. It’s an Elvis cathedral. Tonight, the entry into this cathedral is a password: flirtation.�

U2 made their presence felt at the $2.3 billion Sphere, which stands 366-feet (111 meters) high and 516-feet (157 meters) wide. With superb visual effects, the band’s 25-show residency opened with a splash performing a slew of hits including “Mysterious Ways,� “Zoo Station,� “All I Want is You," “Desire" and new single “Atomic City.�

On many occasions, the U2 band members were so large on screen that it felt like Bono intimately sang to the audience on one side while The Edge strummed his guitar to others on a different side.

The crowd included many entertainers and athletes: Oprah, LeBron James, Matt Damon, Andre Agassi, Ava DuVernay, Josh Duhamel, Jason Bateman, Jon Hamm, Bryan Cranston, Aaron Paul, Oscar de la Hoya, Henrik Lundqvist, Flava Flav, Diplo, Dakota Fanning, Orlando Bloom and Mario Lopez.

After wrapping up The Beatles’ jam “Love Me Do,� Bono recognized Paul McCartney, who was in attendance, saying “Macca is in the house tonight.� He acknowledged Sphere owner James Dolan’s efforts for spearheading a venue that’s pushing forward the live concert audio landscape with 160,000 high-quality speakers and 260 million video pixels.

The Sphere is the brainchild of Dolan, the executive chair of Madison Square Garden and owner of the New York Knicks and Rangers. of the venue on notebook paper.

“I’m thinking the that the Sphere may have come into existence because of Jim Dolan trying to solve the problem that The Beatles started when they played Shea Stadium,� Bono said. “Nobody could hear you. You couldn’t hear yourselves. Well, the Sphere’s here. … Can you hear us?�

The U2 frontman pointed into the crowd and shouted out Dr. Dre, Snoop Dogg and Jimmy Iovine. At one point he became emotional when he dedicated a song to the late Jimmy Buffett’s family, who were also in attendance.

Afterward Bono spoke about performing onstage for the first time without drummer Larry Mullen Jr., . He acknowledged Dutch drummer Bram van den Berg’s birthday and him filling in for Mullen.

“I would like to introduce you to the only man who could stand, well, sit in his shoes,� said Bono, who walked toward Berg as some in the crowd began to sing “Happy Birthday.� He handed the microphone to Berg, who offered a few words.

“Let there be no mistake, there is only one Larry Mullen Jr,� Berg said.

As U2 wrapped up the show, a bright light shined from the ceiling and the massive screen began to fill with images of birds, insects and reptiles above a lake. The band closed its first Sphere concert with “Beautiful Day," which won three Grammys in 2001.